Researchers in Taiwan conducted a randomized controlled trial on 52 ophthalmology patients. Their results indicated the supplement’s beneficial effects and revealed potential mechanisms implicated in dry-eye syndrome (DES).

“These findings support the potential of targeted nutritional supplementation as a safe and effective strategy for alleviating DES symptoms, offering an alternative to conventional treatments that exclusively focus on symptom management,” they wrote in Antioxidants.

Dry eye syndrome

Dry eye syndrome affects between 10% and 30% of Europeans, causing symptoms of discomfort and visual impairment. Experts explain that DES happens when the eyes do not make enough tears to stay wet or when the tears do not work correctly.

People over the age of 50, women with hormonal changes such as pregnancy or menopause, those who look at screens for long periods and contact lens wearers may be more at risk.

The current study noted that inflammation is a key mechanism underlying DES. People with the condition may develop an adaptive immune response resulting in “decreased lacrimal secretion and associated ocular surface discomfort.”

Beneficial nutrients

Recent research highlights the influence of diet, suggesting that certain nutrients such as omega-3 fatty acids, protein and vitamins A, C and E are associated with a lower risk of DES.

These nutrients help to address the inflammation and oxidative stress associated with the condition.

Lutein and zeaxanthin are acknowledged to be beneficial for eye health, helping to absorb blue light and protecting the retina from damage. Their anti-inflammatory and antioxidant properties may help to regulate the immune response, and previous studies suggest they improve tear production.

Study details

Researchers randomly assigned 52 participants between the ages of 20 and 80 with moderate or severe DES to take a supplement containing 45 mg/day EPA (eicosapentaenoic acid), 30 mg/day DHA (docosahexaenoic acid), 30 mg/day lutein and 1.8 mg/day zeaxanthin or placebo for 12 weeks. Participants maintained their usual diet throughout the study.

Assessments included Schirmer’s test and the ocular surface disease index (OSDI), blood or tear oxidative stress, antioxidant capacities and tear inflammatory indicators.

The results showed a significant increase in tear secretion and a reduction in OSDI scores in participants taking the supplement. Inflammatory markers, such as interleukin (IL)-6 and IL-8, were also decreased in this group.

“After 12-week supplementation, the supplement group displayed a significant OSDI decrease of 6.6 points compared with the control group, corroborating the antioxidant and anti-inflammatory properties of fish oil, lutein and zeaxanthin,” the researchers wrote.

They also noted that antioxidant capacity and oxidative stress were both reduced in the control group.

“This paradoxical observation may reflect the complex role oxidative stress plays in the clinical progression of DES,” they wrote. “The increase in oxidative stress could lead to the depletion of antioxidant defenses, as the body attempts to counteract the damaging effects of oxidative stress.

“Such depletion may represent an adaptive response to chronic oxidative stress, where cellular protective mechanisms engage antioxidants to neutralize harmful free radicals.”

Source: Antioxidants 2025, 14(1), 103. doi: 10.3390/antiox14010103. “Multicomponent Dietary Supplementation: Impact on Tear Secretion and Ocular Surface Inflammation in Dry Eye Syndrome Patients”. Authors: S-C. Huang et al.

𝐓𝐡𝐞 𝐩𝐫𝐨𝐛𝐢𝐨𝐭𝐢𝐜𝐬 𝐢𝐧𝐠𝐫𝐞𝐝𝐢𝐞𝐧𝐭𝐬 𝐦𝐚𝐫𝐤𝐞𝐭 𝐬𝐢𝐳𝐞 𝐰𝐚𝐬 𝐯𝐚𝐥𝐮𝐞𝐝 𝐚𝐭 𝐔𝐒𝐃 𝟐,𝟖𝟗𝟐.𝟗𝟑 𝐦𝐢𝐥𝐥𝐢𝐨𝐧 𝐢𝐧 𝟐𝟎𝟐𝟐. 𝐈𝐭 𝐢𝐬 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐞𝐝 𝐭𝐨 𝐠𝐫𝐨𝐰 𝐭𝐨 𝐔𝐒𝐃 𝟔,𝟏𝟓𝟑.𝟓𝟔 𝐦𝐢𝐥𝐥𝐢𝐨𝐧 𝐛𝐲 𝟐𝟎𝟑𝟐, 𝐞𝐱𝐡𝐢𝐛𝐢𝐭𝐢𝐧𝐠 𝐚 𝐜𝐨𝐦𝐩𝐨𝐮𝐧𝐝 𝐚𝐧𝐧𝐮𝐚𝐥 𝐠𝐫𝐨𝐰𝐭𝐡 𝐫𝐚𝐭𝐞 𝐨𝐟 𝟕.𝟗% 𝐟𝐫𝐨𝐦 𝟐𝟎𝟐𝟑 𝐭𝐨 𝟐𝟎𝟑𝟐.

𝐌𝐚𝐫𝐤𝐞𝐭 𝐃𝐞𝐟𝐢𝐧𝐢𝐭𝐢𝐨𝐧

Probiotics are live microorganisms that are aimed to have health advantages when taken in or pertained to the body. They can be detected in yogurt and other fermented foods, dietary additives, and beauty commodities. Some bacteria assist in digesting food, demolishing disease-generating cells, or generating vitamins. Several microorganisms in probiotic commodities are similar to microorganisms that organically reside in the bodies.

𝐆𝐞𝐭 𝐄𝐱𝐜𝐥𝐮𝐬𝐢𝐯𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐏𝐚𝐠𝐞𝐬 𝐨𝐟 𝐓𝐡𝐢𝐬 𝐑𝐞𝐩𝐨𝐫𝐭:

https://www.polarismarketresearch.com/industry-analysis/probiotics-ingredients-market/request-for-sample

𝐆𝐫𝐨𝐰𝐭𝐡 𝐃𝐫𝐢𝐯𝐞𝐫𝐬 𝐚𝐧𝐝 𝐎𝐩𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐭𝐢𝐞𝐬

• Several reasons have contributed to the expansion of the probiotics ingredients market in recent years. Among these is the dependence on research and development endeavors. Firms are funding sizeable resources in R&D to advance excessively effective probiotic strains.

• The market size will expand due to the growing healthcare consciousness involving growing disposable income, surging quality of life, aging population, and altering perspective towards healthcare. Also, the effortless obtainability of details regarding prohibitive healthcare on the internet is bestowing approvingly to the rising levels.

𝐊𝐞𝐲 𝐏𝐥𝐚𝐲𝐞𝐫𝐬

The market is portrayed by fierce contention pushed by factors such as inventive commodity offerings and technological progressions. Here is the list of the leading companies operating in the probiotics ingredients market:

• Biocodex Inc. Danone Inc.

• Chr. Hansen Holding A/S

• Lallemand Inc

• and Danisco A/S.

• Probi AB

• Lactosan GmbH & Co.

• ProbioFerm

• Kerry Inc.

• and Kibow Biotech.

𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐟𝐨𝐫 𝐚 𝐃𝐢𝐬𝐜𝐨𝐮𝐧𝐭 𝐨𝐧 𝐭𝐡𝐢𝐬 𝐑𝐞𝐩𝐨𝐫𝐭 𝐁𝐞𝐟𝐨𝐫𝐞 𝐏𝐮𝐫𝐜𝐡𝐚𝐬𝐞:

https://www.polarismarketresearch.com/industry-analysis/probiotics-ingredients-market/request-for-discount-pricing

𝐑𝐞𝐜𝐞𝐧𝐭 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭𝐬

• In November 2020, Kerry Group acquired Bio-K+ International Inc., enhancing its probiotic portfolio in the market.

• In April 2020, Chr. Hansen acquired HSO Health Care to expand its probiotics offerings for women’s health, further strengthening its global microbial platform.

𝐆𝐞𝐨𝐠𝐫𝐚𝐩𝐡𝐢𝐜𝐚𝐥 𝐋𝐚𝐧𝐝𝐬𝐜𝐚𝐩𝐞

• North America

o Bacteria

 Lactobacillus

 Bifidobacterium

 Streptococcus and Enterococcus

o Yeast

 Saccharomyces Cerevisiae

 Saccharomyces Boulardi

 E. Coli

o Spore Formers

o Application Outlook

 Probiotic Food & Beverages

 Probiotic Dietary Supplements

 Animal Feed Probiotics

 Others

o End Use Outlook

 Human Probiotics

 Animal Probiotics

• Europe

o Bacteria

 Lactobacillus

 Bifidobacterium

 Streptococcus and Enterococcus

o Yeast

 Saccharomyces Cerevisiae

 Saccharomyces Boulardi

 E. Coli

o Spore Formers

o Application Outlook

 Probiotic Food & Beverages

 Probiotic Dietary Supplements

 Animal Feed Probiotics

 Others

o End Use Outlook

 Human Probiotics

 Animal Probiotics

𝐒𝐞𝐠𝐦𝐞𝐧𝐭𝐚𝐭𝐢𝐨𝐧 𝐎𝐯𝐞𝐫𝐯𝐢𝐞𝐰

The probiotics ingredients market analysis is mainly based on ingredients, application, end use and region. Based on ingredients analysis, the bacteria segment witnessed the fastest growth. The strains of Lactococcus, Lactobacillus, Bifidobacterium, and Streptococcus are crucial constituents of bacteria-dependent probiotic ingredients.

According to the application, the probiotic food and beverages segment holds a significant revenue share. Growing gut health worries, the surging geriatric population, and the effectiveness of probiotic commodities in offering health advantages are anticipated to profit the food & beverages segment market demand over the forecast period.

Probiotics Ingredients Market, Ingredients Outlook (Revenue – USD Billion, 2019-2032)

• Bacteria

o Lactobacillus

o Bifidobacterium

o Streptococcus and Enterococcus

• Yeast

o Saccharomyces Cerevisiae

o Saccharomyces Boulardi

o E. Coli

• Spore Formers

Probiotics Ingredients Market, Application Outlook (Revenue – USD Billion, 2019-2032)

• Probiotic Food & Beverages

• Probiotic Dietary Supplements

• Animal Feed Probiotics

• Others

Probiotics Ingredients Market, End Use Outlook (Revenue – USD Billion, 2019-2032)

• Human Probiotics

• Animal Probiotics

𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐓𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐭𝐞 𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐑𝐞𝐩𝐨𝐫𝐭 𝐇𝐞𝐫𝐞:

https://www.polarismarketresearch.com/industry-analysis/probiotics-ingredients-market

📌𝐌𝐨𝐫𝐞 𝐓𝐫𝐞𝐧𝐝𝐢𝐧𝐠 𝐋𝐚𝐭𝐞𝐬𝐭 𝐑𝐞𝐩𝐨𝐫𝐭𝐬 𝐛𝐲 𝐏𝐨𝐥𝐚𝐫𝐢𝐬 𝐌𝐚𝐫𝐤𝐞𝐭 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡:

Probiotics Dietary Supplements Market

https://www.polarismarketresearch.com/industry-analysis/probiotics-dietary-supplements-market

Natural Food Colors Market

https://www.polarismarketresearch.com/industry-analysis/natural-food-colors-market

Plant-Based Meat Market

https://www.polarismarketresearch.com/industry-analysis/plant-based-meat-market

Mushroom Market

https://www.polarismarketresearch.com/industry-analysis/mushroom-market

Beta-Glucan Market

https://www.polarismarketresearch.com/industry-analysis/beta-glucan-market

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