Givaudan reveals findings of new clinical study for TurmiPure Gold
In a newly published study in the journal Food & Function, single supplementation with TurmiPure Gold™, in a variety of dietary supplement applications has been shown to deliver similar or increased levels of curcuminoid metabolites to the bloodstream compared to capsules.[1]
TurmiPure Gold™
Givaudan’s TurmiPure GoldTM is a proprietary, clean-label, 100% natural turmeric formulation, which addresses the common challenges associated with turmeric applications in the dietary supplement market, such as high dosage requirements and poor solubility. With a low daily dosage of only 300 mg, it is versatile in many different applications including shots, gummies and sachets, as well as more conventional dietary supplement applications such as capsules and tablets.[2] It is supported by patents.
Impact of dietary supplement matrices on bioavailability of TurmiPure Gold™
Curcumin and curcuminoids are notable bioactive components of the rhizome of Curcuma longa (turmeric). Curcuminoids have low aqueous solubility and poor gastrointestinal absorption.2-4 Studies have documented that curcumin and curcuminoids exhibit low absorption from the gut, rapid metabolism, and rapid systemic elimination.4-6 These factors contribute to the limited bioavailability of curcuminoids. Several approaches have been explored to enhance the absorption of curcuminoids. However, few studies have investigated the impact of the dietary supplement matrix on curcuminoid metabolite absorption.
Study overview
The new study aimed to analyse the absorption of curcuminoids after single supplementation of TurmiPure Gold™ (300 mg) in a variety of dietary supplement applications. The participants included 40 healthy subjects from 18 to 45 years old. Participants consumed the TurmiPure Gold™ in capsules, a ready-to-drink fruit nectar, a sports nutrition bar, a dairy analogue (oat milk), pectin gummies, and a probiotic drink in a randomised, crossover study.
Key findings
In healthy participants (N=40), single supplementation with a dose of 300mg of TurmiPure GoldTM in a variety of applications:
- Distribution and absorption of curcuminoids were equal or better, irrelevant of the dietary supplement application format.
- The bioavailability of curcuminoids was observed to be improved when administered in dietary supplement applications, particularly those containing lipids in a suspended form or polar lipids.
More information about TurmiPure Gold™
TurmiPure GoldTM is available to nutraceutical companies that seek a turmeric solution designed for strong performance in a wide variety of sport and active lifestyle applications. To find out more, access thestudy abstract here. For more information on TurmiPure Gold™ please see the Givaudan Health and Nutrition Hub or contact Givaudan at global.healthandnutrition@givaudan.com.
[1] The influence of food matrix on the bioavailability of curcuminoids from a dried colloidal turmeric suspension: A randomized, crossover, clinical trial
2. S. Gopi, J. Jacob, K. Varma, S. Jude, A. Amalraj, C. A. Arundhathy, R. George, T. R. Sreeraj, C. Divya, A. B. Kunnumakkara and S. J. Stohs, Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open-label Parallel-arm Study, Phytother Res, 2017, 31, 1883-1891.
3. Y. He, Y. Yue, X. Zheng, K. Zhang, S. Chen and Z. Du, Curcumin, inflammation, and chronic diseases: how are they linked?,Molecules, 2015, 20, 9183-9213.
4. S. C. Gupta, B. Sung, J. H. Kim, S. Prasad, S. Li and B. B. Aggarwal, Multitargeting by turmeric, the golden spice: From kitchen to clinic, Mol Nutr Food Res, 2013, 57, 1510-1528.
5. P. Anand, A. B. Kunnumakkara, R. A. Newman and B. B. Aggarwal, Bioavailability of curcumin: problems and promises, Mol Pharm, 2007, 4, 807-818.
6. M. Pulido-Moran, J. Moreno-Fernandez, C. Ramirez-Tortosa and M. Ramirez-Tortosa, Curcumin and Health, Molecules, 2016, 21, 264.
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