The study, published in the journal Obesity, is the first of its kind to investigate the effects of krill oil on muscle mass and strength during diet-induced weight loss.

Growing global interest in weight-loss interventions — from calorie-restricted diets to pharmacological approaches such as GLP-1 receptor agonists — has brought increased attention to the potential health implications of rapid weight reduction.

One concern is the simultaneous loss of skeletal muscle, which can negatively impact metabolic health, physical function and long-term weight maintenance.

Although this study did not include participants on GLP-1 medication, the findings provide relevant insights for a broad range of weight-loss scenarios.

“Although losing weight is often a good thing, one of the unintended consequences is that we don’t only lose fat, but we also lose muscle.”

“In this study, we have found that krill oil can help to preserve our muscle mass and strength as we lose weight. As maintenance of muscle is very important for our overall health and quality of life, these are extremely exciting findings,” says Dr Stuart Gray, a Professor at the University of Glasgow and coauthor of the study.

Clinical study background

The study was based on the premise that weight loss during a fasting diet can lead to a decline in muscle mass, which can negatively impact muscle strength.

The scientists at the University of Glasgow hypothesised that krill oil, as a source of long-chain omega-3 polyunsaturated fatty acids, could minimise this decline. 

They put this theory to the test by enrolling 52 adult participants (between 25-65 years of age with above-average BMI) in the randomised placebo-controlled trial, using krill oil and placebo supplements supplied by Aker BioMarine.

The participants received either 4 g of Superba Boost krill oil per day or 4 g of vegetable oil per day (placebo), both before and during the weight loss period.

During fasting days, participants consumed no more than 500 Kcal during a 2-hour window. On feeding days, participants were allowed to eat normally but were told to avoid overeating.

Results of the trial

The 41 participants who completed the trial underwent several tests following the weight loss period, including handgrip strength, chair rising, body composition and a fatty acid composition analysis. The key results included

• the loss in muscle mass was lower in the krill oil group compared to the placebo group
• the resulting loss in handgrip strength was lower in the krill oil group compared with the placebo group.
• the amount of time to rise out of a chair was shorter for participants taking the krill oil supplements.
• the reduction in systolic blood pressure was greater in the krill oil group than in the placebo group.
• the amount of fatty acids (EPA, DHA) and the omega-3 index were higher among participants in the krill oil group.

Following this experiment, the scientists concluded that 4 g per day of krill oil during a period of weight loss can help reduce losses in muscle mass and strength, making it a viable strategy to mitigate some of the associated unwanted effects.

They also noted that future studies are recommended to explore the underlying mechanisms behind the impact of krill oil in terms of preserving muscle function.

“We are pleased to continue our work with the University of Glasgow to further explore krill oil and its positive effects on muscle mass and function,” says Line Johnsen, SVP Human Health Ingredients R&D, Aker BioMarine.

“We have previously conducted scientific studies with Dr Gray and his team to show how the important nutrients found in krill impact muscle strength and mass with age, and this follow-up study helps strengthen our understanding of this area.”

The liposomal supplements market is on a trajectory of robust and sustained growth, fueled by increasing consumer demand for high-bioavailability nutrition solutions and rapid progress in liposomal delivery systems. In 2023, the global industry was valued at US$ 323.4 million. According to market projections, it will grow at a CAGR of 7.8% from 2024 to 2034, crossing the US$ 741 million mark by the end of 2034. This expansion reflects not only technological innovation in supplement design but also changing dietary habits, evolving medical recommendations, and efforts by major players to tap into underserved geographic markets.

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What Are Liposomal Supplements and Why Are They Important?

Liposomal supplements are advanced nutritional formulations that utilize liposomes-microscopic, phospholipid-based vesicles-to encapsulate nutrients for delivery into the body. Liposomes mimic natural cell membranes, allowing them to merge with cells in the digestive tract, protecting the supplement’s active ingredients as they travel through the harsh environment of the stomach, and greatly improving nutrient absorption in the small intestine.

The upshot is significantly improved bioavailability compared to conventional supplementation. This technology works for both water-soluble and fat-soluble nutrients, making it ideal for vitamins (such as C, D, and B12), minerals (like magnesium and calcium), antioxidants (such as glutathione and curcumin), and specialty nutraceuticals. Liposomal supplements are commonly available in liquid or powdered forms for commercial and consumer use.

Market Drivers: Why Is the Market Growing?

Growing Global Demand for Additional Supplements

A major driver of the liposomal supplements market is the surge in consumer demand for supplemental nutrients. Lifestyle changes, food processing, and intensive agriculture have collectively led to a tangible and well-documented decline in the nutrient content of modern diets. According to a recent National Geographic study, today’s fruits and vegetables are often deficient in critical nutrients like phosphorus, calcium, and vitamin C compared to produce from a decade ago.

Increasing concerns about health and wellness, along with heightened awareness around dietary gaps, have prompted a larger portion of the population to seek out supplements. In fact, CDC surveys note that nearly 14% of adults in the U.S. reported using more than four dietary supplements in just the past month-a figure expected to rise, further fueling market demand.

Advanced Liposomal Technology Investment

Another significant factor bolstering market growth is the wave of investments and research in next-generation liposomal delivery systems. Companies are refining the size, stability, and composition of liposomes to target specific nutrients and optimize absorption.

For example, in 2023, Pharmako Biotechnologies, in partnership with Gencor, launched PlexoZome-a new platform enabling on-site manufacturing of liquid liposomal supplements. At the same time, brands like Codeage introduced innovative products such as Liposomal NAD+ Ultra Supplement capsules, catering to the growing consumer appetite for targeted solutions promoting cellular health and longevity.

These breakthroughs are enabling the expansion of liposomal supplement offerings into increasingly diverse and complex nutrient categories.

Market Overview: Products, Applications, and Channels

The liposomal supplements market is highly segmented by product type, application, and distribution channel:

By Product Type: Vitamins and minerals (vitamin C, D, B12, calcium, magnesium), antioxidants (glutathione, curcumin), herbal extracts, nutraceuticals, and others.

By Application: Dietary supplementation, sports and fitness, medical and clinical nutrition, among others.

By Distribution Channel: Dominated by online retail stores, which held the largest share in 2023 owing to the global shift towards e-commerce and direct-to-consumer models, followed by direct sales and other specialty outlets.

Regional Analysis: North America at the Forefront

North America, particularly the United States, has established itself as the global leader in the liposomal supplements market. This dominance is propelled by a robust ecosystem of pharmaceutical and nutraceutical companies that are consistently investing in advanced delivery systems, rapid product development, and aggressive market outreach. The region has especially seen significant growth in the adoption of glutathione-based supplements, known for their potent antioxidant properties.

The awareness and uptake of liposomal supplements are also rising in emerging markets across Asia Pacific, Latin America, and the Middle East & Africa. Companies are actively targeting these regions by launching education campaigns and forming distribution partnerships to overcome the barrier of limited consumer awareness that still restrains market potential in certain developing countries.

Key Players and Competitive Landscape

The global liposomal supplement industry is characterized by widespread competition among manufacturers focused on organic growth, new product launches, and technological innovation. Some of the leading names include:

Terry Naturally Vitamins

LivOn Labs

NOW Foods

Pure Encapsulations

Quicksilver Scientific

Mercola

Thorne

Nutrex Hawaii

Designs for Health

NutroCology

In recent years, new product launches and technology upgrades have given these players an edge-for example, Specnova’s LipoVantage technology, and Life Extension’s highly absorbable vitamin C hydrogel formula.

Innovation and Market Trends

Continuous R&D and demand for clean-label, science-backed supplements are propelling the market. Consumers are increasingly seeking supplements for targeted health concerns, such as immune support, healthy aging, sports recovery, and cognitive function. Brands are responding by introducing liposomal forms of popular ingredients for specific outcomes-an area likely to drive future growth.

Conclusion: A Promising Decade Ahead for Liposomal Supplements

With its ability to address bioavailability challenges and meet rising global nutritional needs, the liposomal supplements market is poised for sustained expansion, set to surpass US$ 741 million by 2034. Both technological innovation and heightened consumer demand are fueling growth. As companies extend their global reach and diversify portfolios, liposomal supplements are set to become a mainstream solution for effective, potent nutrition worldwide.

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