WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_ad_91'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = 'a:29:{s:2:\"id\";s:2:\"91\";s:8:\"space_id\";s:1:\"8\";s:9:\"space_ids\";N;s:8:\"priority\";N;s:13:\"withdrawal_id\";N;s:7:\"ad_name\";s:15:\"Smoothie Diet 3\";s:11:\"buyer_email\";s:19:\"m.karam@outlook.com\";s:5:\"title\";s:0:\"\";s:11:\"description\";s:0:\"\";s:6:\"button\";s:0:\"\";s:3:\"url\";s:0:\"\";s:3:\"img\";s:0:\"\";s:4:\"html\";s:215:\"<center>\r\n<a href=\"https://bipns.com/redirect/Supplements/SmoothieDiet3.html\r\n\" target=\"_blank\"><img src=\"https://bipns.com/wp-content/uploads/2024/05/SmoothieDiet-3-728x90-1.jpg\" alt=\"Smoothie Diet\"></a>\r\n</center>\";s:8:\"ad_model\";s:3:\"cpm\";s:8:\"ad_limit\";s:10:\"2147385538\";s:7:\"capping\";s:1:\"0\";s:14:\"optional_field\";s:0:\"\";s:10:\"additional\";N;s:4:\"cost\";s:4:\"0.00\";s:4:\"paid\";s:1:\"2\";s:6:\"starts\";N;s:4:\"ends\";N;s:15:\"show_in_country\";N;s:16:\"show_in_advanced\";N;s:6:\"p_time\";N;s:6:\"p_data\";N;s:7:\"p_error\";N;s:8:\"w_status\";N;s:6:\"status\";s:6:\"active\";}', `autoload` = 'off' WHERE `option_name` = '_site_transient_bsa_ad_91'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_stats`]
UPDATE wp_bsa_pro_stats SET custom = 72, action_time = 1767916800 WHERE id = 52000 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_ads`]
UPDATE wp_bsa_pro_ads SET ad_limit = `ad_limit` - 1 WHERE id = 91 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_8'

Smoothie Diet

Dietary Supplements News,News

Botanical extracts rival semaglutide weight loss

By │Published On: January 9, 2026│3.9 min read│Views: 27│0 Comments on Botanical extracts rival semaglutide weight loss│

While many ingredients claim to increase production of glucagon-like peptide-1 (GLP-1), an incretin hormone that signals satiety, few have robust clinical trials proving their case and correlating it with weight loss.

A new clinical trial published in Medicina touts significant weight loss benefits and GLP-1 boosts for two botanical extracts, Dichrostachys glomerata and Cissus quadrangularis.

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_ad_68'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = 'a:29:{s:2:\"id\";s:2:\"68\";s:8:\"space_id\";s:1:\"6\";s:9:\"space_ids\";N;s:8:\"priority\";N;s:13:\"withdrawal_id\";N;s:7:\"ad_name\";s:14:\"SaltWaterTrick\";s:11:\"buyer_email\";s:19:\"m.karam@outlook.com\";s:5:\"title\";s:0:\"\";s:11:\"description\";s:0:\"\";s:6:\"button\";s:0:\"\";s:3:\"url\";s:0:\"\";s:3:\"img\";s:0:\"\";s:4:\"html\";s:214:\"<center>\r\n<a href=\"https://bipns.com/redirect/Supplements/SaltWaterTrick.html\" target=\"_blank\"><img src=\"https://bipns.com/wp-content/uploads/2024/04/Renew-Saltwatertrick.png\" alt=\"Salt Water Trick\"></a>\r\n</center>\";s:8:\"ad_model\";s:3:\"cpm\";s:8:\"ad_limit\";s:10:\"2147345378\";s:7:\"capping\";s:1:\"0\";s:14:\"optional_field\";s:0:\"\";s:10:\"additional\";N;s:4:\"cost\";s:4:\"0.00\";s:4:\"paid\";s:1:\"2\";s:6:\"starts\";N;s:4:\"ends\";N;s:15:\"show_in_country\";N;s:16:\"show_in_advanced\";N;s:6:\"p_time\";N;s:6:\"p_data\";N;s:7:\"p_error\";N;s:8:\"w_status\";N;s:6:\"status\";s:6:\"active\";}', `autoload` = 'off' WHERE `option_name` = '_site_transient_bsa_ad_68'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_stats`] UPDATE wp_bsa_pro_stats SET custom = 89, action_time = 1767916800 WHERE id = 51999 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_ads`] UPDATE wp_bsa_pro_ads SET ad_limit = `ad_limit` - 1 WHERE id = 68 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

Salt Water Trick

Not only did researchers demonstrate the impact of the extracts, but they also compared their use as a dietary supplement side by side with semaglutide, a popular GLP-1 receptor agonist (RA) drug.

Why are botanical ingredients important for weight management?

“We now have the strongest evidence yet that these extracts support GLP-1 activity through natural pathways in the body, helping regulate appetite, reduce body fat and improve key markers of metabolic health,” said Julius Oben, Ph.D., professor of nutritional biochemistry at the University of Yaounde in Cameroon and lead investigator, via press release from Gateway Health Alliances.

Gateway Health Alliances is an ingredient supplier focused on science-backed ingredients for weight management and supplied the botanical ingredients for the study, which it markets as Dyglomera and CQR-300.

GLP-1 RAs are a boon for weight management because they increase satiety, leading to decreases in caloric intake. Yet many barriers exist that prevent their use, including affordability, side effects and adversity to injections. Oral semaglutide is an option recently approved by the FDA for weight loss, but cost and side effects may still be issues.

Related:Strong growth predicted for dietary supplements market, especially for botanicals, gummies and weight management

Several supplement ingredients such as probiotics and fibers are purported to increase endogenous GLP-1 production but have not been compared directly to semaglutide, which has a much longer half-life than GLP-1 produced in the body.

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_4'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_4'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_4'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_4'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_4'

Dietary supplements formulated with botanical extracts provide an avenue for supporting weight management at reduced cost with fewer side effects,tapping into two growing trends for the industry.

What are the key takeaways from this weight loss study?

The botanicals studied increased GLP-1 levels and decreased levels of dipeptidyl peptidase-4 (DPP-4), an enzyme that breaks down GLP-1.

Both ingredients led to similar decreases in body weight, body fat, fasting glucose and cholesterol levels as oral semaglutide. All participants on active ingredients experienced reduced energy intake and improved satiety.

What botanical ingredients were studied?

The two extracts studied were Dichrostachys glomerata and Cissus quadrangularis, two botanicals commonly used in Africa and Asia for weight loss.

Related:3 trending ways food and supplement brands can support weight management

What were the details of the clinical trial?

  • Design: Randomized double-blind placebo-controlled trial.

  • Study size: 228 participants completed the study.

  • Length: 16 weeks. The researchers did not provide participants with specific instructions for diet or exercise.

  • Dosage: Participants received either 400 mg/d D. glomerata extract, 300 mg/d C. quadrangularis extract, oral semaglutide (starting dose 3 mg/d for first four weeks, ramped up to 7 mg/d for second four weeks, then 14 mg/d for the remainder of the study), or placebo.

  • Outcomes measured: Blood GLP-1 levels, DPP-4 activity, body weight, body fat, fasting glucose, cholesterol, triglycerides, energy intake (estimated from food diaries) and satiety (measured using a validated visual analog scale questionnaire).

What were the results?

By the end of the trial, all participants receiving an active (either semaglutide or the botanical extracts) experienced the following statistically significant – and often clinically relevant – changes as compared to placebo:

  • Increase in GLP-1 levels.

  • Decrease in DPP-4 activity.

  • Reduction in body weight (5% or greater).

  • Reduction in body fat percentage (10% or greater).

  • Decrease in total cholesterol and triglycerides.

  • Reduction in calorie intake (16% or greater).

  • Increase in satiety score (25% or greater).

Related:Complementing the GLP-1 weight management journey – article

While semaglutide led to the greatest numerical improvements for all measurements, the changes elicited by both D. glomerata and C. quadrangularis were comparable.

How does this build upon prior research?

Scientists previously evaluated D. glomerata in a clinical trial, finding the extract had a beneficial impact on weight and mood, but they did not measure GLP-1 or DPP-4 levels. Researchers studied the botanical with and without caffeine, observing improvements in weight and satiety in both instances.

C. quadrangularis has widely been studied in the literature for various effects including anti-inflammatory and anti-microbial properties as well as benefits for bone health. Both a meta-analysis on the botanical and a study specifically on the CQR-300 extract point to strong benefits for weight management.

Akkermansia species have received attention in recent months because of their impact on weight loss and GLP-1 activity, but results to date are mixed. One clinical trial showed obese subjects who supplemented with an A. muciniphila probiotic did not experience changes in GLP-1 levels, whereas another trial showed both a live probiotic and postbiotic form of the species increased GLP-1.




Source link

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034641', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034641', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034641', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034641', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]
UPDATE `wp_options` SET `option_value` = '1768034641', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_1'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_3'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_ad_63'

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_stats`] UPDATE wp_bsa_pro_stats SET custom = 84, action_time = 1767916800 WHERE id = 52039 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_bsa_pro_ads`] UPDATE wp_bsa_pro_ads SET ad_limit = `ad_limit` - 1 WHERE id = 63 LIMIT 1

WordPress database error: [UPDATE command denied to user 'u117406468_wyYa1'@'127.0.0.1' for table `u117406468_rofUe`.`wp_options`]UPDATE `wp_options` SET `option_value` = '1768034640', `autoload` = 'off' WHERE `option_name` = '_site_transient_timeout_bsa_space_6'

puravive

Written by : Editorial team of BIPNs

Main team of content of bipns.com. Any type of content should be approved by us.

Share this article:

Leave A Comment