A small pilot study suggests that pairing a Mediterranean diet with supplements containing phytosterols and omega-3 fatty acids may help improve cholesterol and reduce body fat in menopausal women.

The research published in Frontiers in Nutrition, followed menopausal and perimenopausal women who adapted a Mediterranean-style eating plan and added two daily supplements. One was a phytosterol-based formula containing bergamot, prickly pear extract and vitamin B1. The other was an omega-3 fatty acid supplement, recommended because of its cardiovascular benefits. After just a few months, participants showed improvements in cholesterol levels and body composition.

Menopause often comes with hormonal and metabolic changes that can raise cholesterol, increase abdominal fat and increase cardiovascular risk. Heart disease is the leading cause of death for women, and managing cholesterol is an important part of prevention.

The Mediterranean Diet—built around vegetables, fruits, legumes, whole grains, olive oil and fish—has long been linked to heart health. Phytosterols, or plant sterols, and omega-3s are also well known for helping lower cholesterol and triglycerides. This study set out to see whether combining diet with these supplements could offer extra support during the menopausal transition.

How Was the Study Conducted?

The Italian study team looked at 14 women, 9 of whom were menopausal (with an average age of about 60) and 5 who were perimenopausal (with an average age of about 53). All of them were under the care of a nutrition specialist for dietary intervention due to high cholesterol and weight management. None of the participants were taking lipid-lowering medications or supplements at the start. Each woman received a personalized Mediterranean diet meal plan along with two supplements.

The women were tracked for two to seven months. During that time, researchers measured cholesterol, triglycerides, body weight, waist size and overall body composition.

What Did the Study Find?

At the start, the women had an average BMI of around 27, placing most of them in the overweight or obese category. Their cholesterol profiles showed high total cholesterol and LDL (“bad”) cholesterol, along with low HDL (“good”) cholesterol. About one in five of the menopausal participants also had elevated triglycerides.

After just a few months on the Mediterranean diet meal plan plus the two supplements, the women showed clear improvements across several key markers. Total cholesterol and LDL cholesterol dropped, while HDL cholesterol rose significantly.

The gains in HDL were especially intriguing—up to 65% in menopausal women and 58% in perimenopausal women. These increases are clinically meaningful because low HDL is considered a risk factor for metabolic syndrome and cardiovascular disease. Many women also improved their total cholesterol-to-HDL ratio, lowering it to a range linked with better heart disease prevention.

Researchers also analyzed triglycerides, but the most consistent improvements were seen in cholesterol levels and ratios.

The changes weren’t limited to bloodwork. On average, the women lost body fat, trimmed their waistlines and lowered their BMI. Their waist-to-hip ratios improved as well, suggesting a healthier pattern of fat distribution. In some cases, body fat mass dropped by nearly one-third during the study period.

Like all studies, this one certainly has its limitations—small size being a major one. This study was also conducted in Italy with a group of Italian participants, so it’s difficult to say just how applicable the findings could be to other groups.

How Does This Apply to Real Life

Even though this was a small pilot study, the results match what experts have been saying for years: the Mediterranean diet is one of the best for heart health. Building meals around vegetables, fruits, beans, whole grains, olive oil and fish can go a long way toward keeping cholesterol in check.

Supplements like phytosterols and omega-3s may provide an extra boost, particularly during menopause. And in this study, improvements were seen even though none of the women were taking cholesterol-lowering medications—suggesting that diet and supplements can make a measurable difference.

That said, these aren’t magic pills. How well they work depends on your overall diet, lifestyle, and even your genetics. It’s also important to remember the limitations: this study included just 14 women, didn’t use a control group and only ran for a few months. The results are promising but very preliminary. Larger, longer studies are needed to know whether this combination truly makes a lasting difference.

Our Expert Take

A Mediterranean diet eating pattern remains one of the most reliable ways to support heart health. Supplements, like the ones in the study, may offer additional benefits, but they should be seen as a complement to—not a substitute for—healthy eating and lifestyle habits. A health care professional can help determine whether these options fit into an individual’s overall prevention plan.

The FDA announced they have initiated the approval of leucovorin calcium tablets (Wellcovorin; GSK) for patients with cerebral folate deficiency (CFD), which the agency claims can cause developmental delays with features of autism spectrum disorder (ASD).

The action is based on an FDA-conducted systematic review of published literature between 2009 and 2023, including published case reports and mechanistic data.¹ The autistic features cited by the FDA include seizures and problems with movement and coordination.

GSK, the manufacturer of leucovorin calcium and the holder of the medicine’s new drug application, is working with the FDA on a process to include information needed for the safe use of the drug in patients with CFD on its label. It is unknown how long the approval process may take for leucovorin calcium.¹

What is Cerebral Folate Deficiency?

CFD is a neurological syndrome that begins to impact development at age 2. Low levels of 5-methyltetrahydrofolate, an essential B-vitamin, in the brain can cause CFD. Children may lose some mental and motor skills, while others may experience intellectual disability, difficulty speaking, or recurrent seizures. Motor issues, including tremors or ataxia, can become severe as the disorder progresses. Some research has demonstrated that cerebral folate receptor alpha (FRα) antibodies can be observed in ASD.^2-4

According to the Department of Health and Human Services, autoimmune forms of CFD are the most common presentations. In this form, autoantibodies mistakenly attack the body’s folate transport system, which yields severe neurological symptoms.

It is critical to note that not every individual with ASD harbors FRα autoantibodies. One analysis found that the pooled prevalence of ASD in individuals with CFD was 44%, while the pooled prevalence of CFD in ASD was 38%, with significant variation across included studies. Another found that FRα autoantibodies were identified in 58% to 76% of children with ASD.^3,5,6

What is Leucovorin?

Leucovorin, also known as folinic acid, helps bypass the defective folate transport system and deliver the active form of folate directly to the brain. It is typically used in the treatment of methotrexate toxicity and chemotherapy regimens, while also occasionally used as an alternative agent for megaloblastic anemia when oral intake of folic acid is not possible. It first received FDA approval in 2002.⁷

According to the FDA’s meta-analysis, which encompassed 23 publications over 15 years, leucovorin demonstrated effectiveness in reducing the symptoms of CFD. FDA investigators found that 85% of patients experienced some form of clinical benefit, including improved communication capabilities. Furthermore, efficacy data on the use of leucovorin specifically for the autoimmune presentation of CFD suggest benefits, but the FDA cautions that the data must be replicated in future research.^3,5,7

Some adverse effects are possible with leucovorin but are generally mild in nature. One analysis reported common effects, including aggression, excitement or agitation, headache, insomnia, and increased tantrums. However, these authors concluded that leucovorin appears safe and generally well-tolerated. The FDA stated that leucovorin is generally well-tolerated based on its established safety profile in other approved indications.^3,5,7

What Can Pharmacists Do?

Pharmacists stand to be critical harbingers of trusted, up-to-date medical information in the wake of this announcement. HHS noted in their fact sheet that off-label use of leucovorin has increased substantially in recent years; however, it is critical for pharmacists to explain that ingesting folate through over-the-counter supplements has not been approved by the FDA and may be harmful. Even if a patient presents as using leucovorin, a pharmacist should evaluate their medication history and ensure there are no drug-drug interactions or contraindications that may harm the patient.⁵

Research on this topic is ongoing. The FDA explained in their news release that there are limitations on available data for the use of leucovorin in this population. Pharmacists should counsel patients that, although the FDA is initiating its approval process, leucovorin may not be a stand-alone cure for autistic symptoms. Parents and caregivers of children with ASD should ensure that, above all, the well-being of their child is of top priority, and that novel treatments should be rigorously examined before use.¹

Pharmacists should monitor the approval process of leucovorin and ensure they are prepared to educate patients if and when the drug is made available.

REFERENCES

1. FDA. FDA takes action to make a treatment available for autism symptoms. News Release. Released September 22, 2025. Accessed September 23, 2025. https://www.fda.gov/news-events/press-announcements/fda-takes-action-make-treatment-available-autism-symptoms

2. Cerebral folate deficiency. National Organization for Rare Disorders. Updated August 22, 2019. Accessed September 23, 2025. https://rarediseases.org/rare-diseases/cerebral-folate-deficiency/

3. Rossignol DA, Frye RE. Cerebral folate deficiency, folate receptor alpha autoantibodies and leucovorin (folinic acid) treatment in autism spectrum disorders: A systematic review and meta-analysis. J Pers Med. 2021;11(11):1141. doi:10.3390/jpm11111141

4. Frye RE, Sequeira JM, Quadros EV, et al. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol Psychiatry. 2012;18(3):369-381. doi:10.1038/mp.2011.175

5. Frye RE, Rossignol DA, Scahill L, et al. Treatment of folate metabolism abnormalities in autism spectrum disorder. Seminars in Pediatric Neurology. 2020;25:100835. doi:10.1016/j.spen.2020.100835

6. Department of Health and Human Services. Autism announcement fact sheet. Released September 22, 2025. Accessed September 23, 2025. https://www.hhs.gov/press-room/autism-announcement-fact-sheet.html

7. Hedge VS, Nagalli S. Leucovorin—StatPearls [Internet]. National Library of Medicine. Last Updated July 3, 2023. Accessed September 23, 2025. https://www.ncbi.nlm.nih.gov/books/NBK553114/

Matcha contains tannins and other compounds that can block iron absorption, but for most people, it’s not a major health risk. With a few simple tweaks, you can still enjoy matcha without worrying about your iron levels. 

How Matcha Affects Your Iron Absorption

Matcha is a type of powdered green tea well known for its high antioxidant content. It also contains a unique combination of caffeine and L-theanine, a natural amino acid that has been shown to help with energy, stress, and focus, often making it a gentler alternative to coffee.

Matcha also contains tannins, a type of polyphenol that can bind iron in the digestive tract, making it harder for the body to absorb. Because matcha is much more concentrated than regular green tea, it contains more of these polyphenols that will block your body from absorbing iron.

“This mostly affects non-heme iron (from plants), not heme iron (from meat), which is absorbed more easily and isn’t as affected by polyphenols.“ Debbie Petitpain, MBA, RD, a spokesperson for the Academy of Nutrition and Dietetics, told Verywell. 

Studies suggest even just one serving of green tea with a meal can reduce non-heme iron absorption by up to 60%-90%, with matcha having an even stronger effect on iron absorption, adds Petitpain. 

What Iron-Rich Foods Are Affected?

Drinking matcha could affect the absorption of some plant-based sources of iron, including:

• Dark leafy greens 
• Lentils 
• Legumes
• Tofu
• Nuts
• Seeds
• Whole grains

Can Other Foods Block Iron Absorption?

Macha isn’t the only drink that can interfere with iron absorption. Other foods contain tannins and, when consumed in large amounts, could reduce how much iron your body takes in.

They include:

• Black tea
• Green tea
• Oolong, tea,
• Red wine,
• Cocoa

How Do You Know If You’re Iron-Deficient?

It can be difficult to tell when someone is experiencing iron deficiency, but some early signs include:

• Fatigue 
• Pale skin
• Dizziness or lightheadedness 
• Cold hands and feet 
• Shortness of breath
• Chest pain
• Headaches
• Brain fog
• Brittle nails 

If you’re unsure whether your iron levels might be low, ask your provider for testing, adds Petitpain, it’s easy, quick and covered by most health insurances.

Who Might Be More at Risk? 

Matcha is safe for most people, but be careful if you drink it frequently or already struggle with low iron levels. 

Those who should be more mindful of their matcha intake include:

• Pregnant and breastfeeding individuals: Their bodies use more iron than usual. 
• Menstruating women: Regular blood loss can increase iron needs. 
• Vegetarians or vegans: They rely on plant-based iron, and matcha could potentially block more of their iron intake. 

How to Enjoy Matcha Worry Free  

One cup of matcha daily is generally fine, but multiple servings or drinking it with meals can interfere with iron absorption, and the caffeine content can also add up, said Yoshua Quinones, MD, clinical instructor at NYU Grossman School of Medicine.

Matcha can contain up to 45 milligrams (mg) of caffeine per gram (g), while an 8-oz cup of brewed coffee may have up to 120 mg.

Quinones added that vitamin C enhances iron absorption by making it easier for your gut to absorb iron through a process called chelation and reduction.

Here’s how to best enjoy matcha while caring for your overall health: 

• Stick to just one cup a day or about 1 to 3 g 
• Drink it between meals, about 1 to 2 hours before or after eating
• Monitor your sugar intake since matcha is naturally bitter and is often paired with sweeteners
• Add vitamin C-rich foods, like citrus or bell peppers, to meals to boost iron absorption

Delray Beach, FL, Sept. 23, 2025 (GLOBE NEWSWIRE) — According to a research report by MarketsandMarkets, the Vitamin K2 Market by Product Type (MK-4, MK-7), Source (Natural Origin, Synthetic Origin), Application Form (Capsules & Tablets, Powder & Crystalline, Oils & Liquid), Application (Pharmaceutical, Functional Food & Beverages, Health Supplements), Function, and Region – Global Forecast to 2029 is poised for impressive growth. The global vitamin K2 market, estimated at USD 139.6 million in 2024, is projected to reach USD 264.7 million by 2029, reflecting a strong CAGR of 13.7% during the forecast period.

Why Vitamin K2 Demand is Surging

Vitamin K2 has gained attention due to its unique role in calcium metabolism, distinguishing it from Vitamin K1, which mainly supports blood clotting. Vitamin K2 helps direct calcium to the bones and away from arteries, contributing to cardiovascular health by reducing the risk of arterial calcification. It also promotes bone mineral density, making it valuable for aging populations and athletes aiming to prevent bone loss.

Growing consumer awareness of health and wellness has further boosted Vitamin K2 demand. As concerns around osteoporosis and cardiovascular health rise, supplements that support bone and heart health have become increasingly popular. The proliferation of both online and retail platforms has also made Vitamin K2 supplements more accessible than ever.

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Natural Origin Segment Leads the Market

The natural origin source segment is expected to hold the largest market share throughout the forecast period. Consumer preference for organic and clean-label products is driving demand for naturally sourced Vitamin K2, such as that derived from natto.

The rising incidence of osteoporosis and cardiovascular diseases further fuels this segment, with companies investing in advanced extraction techniques to ensure high purity and bioavailability. This focus on natural sourcing enhances both product appeal and marketability.

Capsules & Tablets: Preferred Application Form

Among the various application forms, capsules and tablets are experiencing notable growth. These forms are convenient, portable, and provide precise dosing, which is crucial for maintaining consistent intake of Vitamin K2.

Capsules and tablets also offer longer shelf life compared to powders or oils, making them an attractive choice for busy consumers. Advances in encapsulation technology have improved the bioavailability of Vitamin K2 in these forms, ensuring the body effectively absorbs the nutrient.

Europe: A Major Market Player

Europe is poised to occupy a dominant position in the Vitamin K2 market during the forecast period. Key factors include:

• Rising consumer awareness about Vitamin K2’s benefits for bone and cardiovascular health.
• Preference for natural and plant-based supplements, aligning with holistic wellness trends.
• Strong presence of pharmaceutical and dietary supplement companies investing in research and innovation.
• Stringent regulatory frameworks, ensuring product safety and quality, which boosts consumer confidence.

These elements collectively strengthen Europe’s position as a significant market player.

Key Market Players

Leading Vitamin K2 companies in the global market include:

• Gnosis by Lesaffre (NattoPharma) (France)
• Kappa Bioscience AS (Balchem Corp.) (US)
• J-Oil Mills, INC. (PLT Health Solutions, Inc.) (Japan)
• Novozymes A/S, part of Novonesis Group (Denmark)
• Sungen Bioscience Co., Ltd. (China)
• Vesta Nutra (US)
• Richen Nutritional Technology Co., Ltd. (China)
• Menadiona (Spain)
• GF Fermentech (GenoFocus) (Korea)
• AngelYeast Co., Ltd. (China)
• GeneFerm Biotechnology Co., Ltd. (Taiwan)
• Nakoda Chemical Ltd. (India)
• Haihang Industry Co., Ltd. (China)
• Chemicea Limited (India)
• Kyowa Hakko U.S.A., Inc. (US)

These companies are actively innovating and expanding their offerings to meet growing demand, leveraging both natural and synthetic sources to capture wider market segments.

The Vitamin K2 industry is on a strong growth trajectory, driven by increasing health awareness, the benefits of natural origin sources, and the convenience of capsules and tablets. With Europe emerging as a key player and global demand rising, the market offers significant opportunities for pharmaceutical, supplement, and functional food companies looking to capitalize on this health trend.

Frequently Asked Questions

1. What is Vitamin K2 and why is it important?
Vitamin K2 is a fat-soluble vitamin that helps direct calcium to the bones and teeth while preventing its accumulation in arteries. Unlike Vitamin K1, which mainly supports blood clotting, K2 is crucial for bone health and cardiovascular health.

2. What are the key product types of Vitamin K2?
The primary forms of Vitamin K2 in the market are MK-4 and MK-7, each with unique absorption rates and efficacy. MK-7 generally has a longer half-life, making it suitable for daily supplementation.

3. Which source of Vitamin K2 is most preferred?
The natural origin source segment dominates the market, with consumers preferring products derived from natural sources like natto, owing to higher bioavailability and a clean-label appeal.

4. What are the popular application forms of Vitamin K2?
Vitamin K2 is available in capsules & tablets, powders & crystalline forms, and oils & liquids. Capsules and tablets are most popular due to convenience, precise dosing, and longer shelf life.

5. What applications drive the demand for Vitamin K2?
Key applications include pharmaceuticals, functional foods & beverages, and health supplements. Its role in calcium metabolism and bone health makes it particularly valuable for aging populations and health-conscious consumers.

6. Which regions are leading the Vitamin K2 market?
Europe is poised to be a dominant market due to high consumer awareness, strong pharmaceutical infrastructure, and stringent regulatory standards. Other regions are also experiencing growth driven by rising health and wellness trends.

7. What is the projected growth of the Vitamin K2 market?
The global Vitamin K2 market is expected to grow from USD 139.6 million in 2024 to USD 264.7 million by 2029, at a CAGR of 13.7%, reflecting increasing consumer demand and awareness.

8. Who are the key players in the Vitamin K2 market?
Leading companies include Gnosis by Lesaffre (NattoPharma), Kappa Bioscience, J-Oil Mills, Novozymes, Sungen Bioscience, Vesta Nutra, Richen Nutritional Technology, Menadiona, GF Fermentech, AngelYeast, GeneFerm Biotechnology, Nakoda Chemical, Haihang Industry, Chemicea Limited, and Kyowa Hakko U.S.A., Inc.

Matchaful, the matcha tea shop that opened first on Canal and West Broadway in 2019, is coming to Independence Plaza at Harrison and Greenwich. (Thanks to A., A. and V. for the shots and info.)

Hannah Habes, the founder and “chief matcha officer,” said the location will open definitely before the end of the year, though they are still working through the timeline. (One neighbor noted that the space was being used as storage while the 40 Harrison residential lobby was renovated.)

I spoke to Hannah deep in the pandemic — in May 2020 — when she had just opened her first brick and mortar after first popping up at Smorgasburg in 2017. Things came together quickly after that; she now has seven locations in the city, including Soho and Brookfield.

Her story is a good one: She started working for Big Food right out of college, representing — and eating — many of the most popular brands: Pepsi, Chewy granola bars, Gatorade. But by her late 20s she was wrestling with all sorts of health issues and after visits to a half dozen doctors with no diagnosis in hand, she decided to make a radical change in her diet.

She embarked on a self-described “health journey,” trying to eat cleaner and simpler. “I wanted to feel better, and I wanted to consume things that made me feel better.” And in the midst of it, her husband came home from a trip to Japan with a little packet of matcha powder as a souvenir. She was hooked after the first brew. And the more she learned about it, the more she was convinced she was on to something.

“Matcha is a green tea, but it’s so much more than that,” she says. “It has been part of Japan’s history for centuries — it was used in battle by Samurai warriors, monks would drink it to help them concentrate during long hours of mediation. It gives you a calm, relaxed energy — a better high in a way than coffee, smoother and more relaxing.”

By 2013, she was flying to Japan to meet with farmers and look at the supply side. The leaves are grown under a certain process that allows for maximum chlorophyll and amino acid production. They are then steamed, dried and ground into a fine powder. The powder is then brewed into the tea, rather than just soaked or strained. You get more antioxidants and a little more caffeine.

After Smorgasborg in 2017, Hannah went door to door to coffee shops to convince them to carry it. Once she had matcha brewing in 30 outlets, she decided it was time for her own brick and mortar. And then the pandemic came and she made a fateful pivot: she ordered glass bottles and expanded her line to include almost everything they have on the menu in the store. She now has a line of DIY matcha for home, subscriptions, and all sorts of products online — matcha sets, whisking bowls, matcha granola, etc. (Before they moved off Canal they were a good location for the TC Shop-Local Gift Guide.)

More TK when they open.

Magnesium carbonate is a “salt” form of magnesium that is available as a supplement and an ingredient in some antacids. While some research supports the use of magnesium alongside attention-deficit hyperactivity disorder (ADHD) medication, the supplement form matters.

Magnesium Supplements May Help ADHD Symptoms

Studies show that people with ADHD tend to have low magnesium levels. Low magnesium levels can affect brain function, which can cause ADHD-like symptoms, such as tiredness, problems with focus, nervousness, and mood changes.

Therefore, combining magnesium supplementation with ADHD medication might effectively reduce symptoms.

However, the form of magnesium matters.

Single-Ingredient Magnesium and ADHD Drugs

Research has shown that single-ingredient magnesium supplements do not interact with ADHD medication.

This includes common ones such as Adderall (dextroamphetamine and amphetamine) and others such as:

• Strattera (atomoxetine)
• Nexiclon XR (clonidine)
• Intuniv (guanfacine)
• Vyvanse (lisdexamfetamine)
• Concerta (methylphenidate)

Therefore, it should be safe to take magnesium supplements and any ADHD medication you’ve been prescribed. In fact, researchers have studied magnesium for its use in addition to medication for reducing ADHD symptoms.

You should always talk to your healthcare provider before combining any supplements, over-the-counter (OTC) medicines, or prescription medications.

Magnesium-Based Antacids May Cause Supplement-Drug Interactions

Antacid forms of magnesium can interact with several medications. Magnesium carbonate is a form of magnesium commonly used in antacids. When combined with other ingredients, such as calcium carbonate or aluminum hydroxide, it can affect the absorption of certain medications.

Since magnesium carbonate can be taken as an antacid, a drug interaction with certain medications that contain methylphenidate (the active ingredient in several ADHD medications), such as Cotempla-XR ODT, is possible.

Other ADHD medications that may interact with antacids include:

• Adderall
• Concerta
• Vyvanse
• Ritalin

However, several other extended-release methylphenidate product labels do not include antacids on the drug interaction list.

Different Forms of Magnesium and ADHD Drugs

Aside from magnesium carbonate, there are many other different “salt” forms of magnesium:

Magnesium hydroxide is another form of magnesium commonly used in antacids. These antacid products may also interact with certain ADHD drugs, so it’s important to check with your healthcare provider or pharmacist. No literature suggests any drug interactions between other forms of magnesium and ADHD medications.

Talk with a healthcare provider, pharmacist, or registered dietitian to help you find the right type of magnesium for your needs.

Other Supplements and ADHD

Apart from magnesium, some people try other supplements to help with their ADHD symptoms.

Some research has been done for:

• Caffeine: Some evidence suggests that high doses of caffeine may modestly improve ADHD symptoms. However, this effect does not appear to be the same at lower doses. Sleeping trouble is a common side effect, which may affect children more than adults.
• Zinc: In people with ADHD, correcting low zinc levels may improve some ADHD symptoms.

Evidence is limited or inconclusive for:

• Ginkgo biloba: Evidence is currently insufficient.
• Melatonin: Research on melatonin’s use for sleep problems in young people with ADHD is limited. However, there is not enough evidence to draw conclusions about its long-term effectiveness and safety.
• Omega-3 fatty acids: Evidence is inconclusive.
• Pycnogenol: Evidence is currently insufficient.

Certain supplements should be avoided, such as:

• St. John’s wort: St. John’s wort is also commonly taken for ADHD. Current evidence, however, suggests that it works no better than a placebo (nontherapeutic treatment). Further, there are reports of adverse events between St. John’s wort and methylphenidate.
• Dimethylamylamine (DMAA): DMAA is a stimulant (a type of drug that speeds up the activity of the central nervous system) sometimes used in dietary supplements marked for improving athletic performance and weight loss. There is no evidence that DMAA is effective for ADHD, but safety is a major concern. DMAA can potentially increase your blood pressure and lead to heart problems, such as heart attacks.

Before starting any supplement or natural product, talk with a pharmacist or healthcare provider.

DataM Intelligence has released an in-depth research report on “Inflammation Supplement Market Size 2025”. This report delivers power-packed insights into key growth drivers, market segmentation, regional trends, CAGR forecasts, revenue performance of top players, and emerging opportunities. Gain a 360° market perspective with detailed analysis on value, volume, and future development trends your ultimate guide to spotting high-impact opportunities and staying ahead in this dynamic market.

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M & A and Product Launches

Major nutraceutical companies have acquired smaller brands specializing in turmeric, omega-3, and botanical anti-inflammatory supplements, hoping to expand their portfolios with trending natural remedies.

Investment surged into startups using novel ingredients-like curcumin nanoparticles, adaptogenic mushroom blends, and polyphenol-rich plant extracts-to develop next-gen inflammation products.

A wave of new supplement launches focused on combinations of anti-inflammatory botanicals, probiotics, and antioxidants, marketed with claims of faster absorption, targeted joint support, and gut health benefits.

Partnerships formed between supplement makers and digital health firms to track inflammation reduction using smart wearables and personalized nutrition apps.

There’s media buzz around “clean label” and vegan inflammation formulas as manufacturers tout non-GMO sourcing and third-party tested purity.

List of Top Key Players:

Nestlé S.A., Procter & Gamble, Johnson & Johnson, Pfizer, Bayer, GlaxoSmithKline, Sanofi, Abbott Laboratories, DSM Nutritional Products, Danone

Forecast Growth Projection:

Global Inflammation Supplement Market Positioned for Strong Growth 2025-2032, Building on the steady momentum of 2024, the market is poised for remarkable expansion as leading players embrace innovative technologies and strategic advancements. This evolving landscape is unlocking lucrative opportunities for businesses to invest, scale, and stay ahead in an increasingly competitive and fast-moving market.

Market Research Process:

The Inflammation Supplement Market research report by DataM Intelligence combines extensive Primary and Secondary research to provide powerful, in-depth insights. It examines key market drivers such as regulatory frameworks, evolving market conditions, competitive dynamics, historical trends, and breakthrough technologies, while spotlighting emerging innovations and potential challenges. This all-inclusive analysis uncovers high-growth opportunities and highlights possible barriers, equipping businesses to tackle market volatility and capture new avenues for success.

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Market Segments:

By Ingredient: Lactobacillus, Bifidobacterium, Saccharomyces, Others

By Product Type: Dietary Supplements, Multistrain Probiotics, Single Strain Probiotics, Prebiotic and Probiotic Combinations, Synbiotics, Functional Foods and Beverages, Probiotic Yogurt, Probiotic Drinks, Probiotic Snacks, Fortified Cereals

By Form, Tablets: Capsules, Gumm!es, Powders

By Application: Digestive Health, Immune Health, Joint Health, Skin Health, Others

By End-User: Infants & Children, Adults, Middle-Aged, Elderly

By Distribution Channel: Supermarkets/Hypermarkets, Online Channel, Specialty Stores, Others

Global Growth Regions:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

Benefits of the Report:

Chapter 1: Opens the report with a comprehensive market overview, highlighting key segments by region, product type, and application. It presents a clear snapshot of market size, growth potential by segment, and both short- and long-term outlook.

Chapter 2: Showcases the most impactful insights, uncovering the emerging trends and disruptive forces shaping the industry’s future.

Chapter 3: Delivers an in-depth competitive landscape analysis of the Inflammation Supplement market, covering revenue shares, strategic moves, and the latest mergers & acquisitions.

Chapter 4: Features detailed profiles of leading players, including their revenue streams, profit margins, product portfolios, and key milestones.

Chapters 5 & 6: Present a granular breakdown of regional and country-level revenue performance, offering a precise view of market size, opportunities, and development prospects worldwide.

Chapter 7: Analyzes market segmentation by product type, revealing the growth potential of each category and spotlighting high-impact.

Chapter 8: Examines application-based market growth, identifying the fastest-expanding sectors and lucrative opportunities for expansion.

Chapter 9: Maps the entire industry supply chain, providing insights into upstream and downstream activities for a complete market perspective.

Chapter 10: Concludes with key findings and actionable takeaways, guiding stakeholders toward strategic decisions and future growth opportunities.

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NAD+ has gotten a lot of hype for its potential to lower inflammation, improve cognitive function, lower the risk of type 2 diabetes and blood pressure issues, and repair the skin.

“There’s a lot of interest and promise in boosting NAD+ because of the research that’s been done in animal models, but the human research hasn’t been as exciting,” Craighead says. “A lot of the studies done with people have been small and for a short duration, and we’re still waiting for bigger studies to come out and provide definitive proof.”

Here are some of the potential health benefits of NAD+ according to research on oral NAD+ precursor supplementation so far.

May Reduce Inflammation

“Reductions in inflammation is the most consistent benefit we see across studies of NR,” Craighead says. But whether the reduction in inflammation linked to NAD+ is also associated with lower chronic disease risk or prognosis hasn’t been proven, Craighead says. “What it does in the long run, we don’t yet know.”

May Improve Cognitive Function for Certain Populations

Researchers suspect the anti-inflammatory effects of NAD+ may offer perks for brain health — in particular, for inflammatory neurodegenerative diseases like Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). And they’ve started to investigate if there is indeed a link.

The researchers believe NR may help prevent Parkinson’s disease from worsening, but more research is needed. “There are some promising signs of benefit, but the benefits are pretty small and only tested in a handful of people,” Craighead says.

May Lower Diabetes Risk

NAD+ may lower the risk of type 2 diabetes by improving insulin sensitivity (how well your body responds to insulin, a hormone that regulates blood sugar).

Craighead says the research is promising but calls for more studies with larger sample sizes.

May Improve Heart Health