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HMO supplements may improve body composition in a weight loss program

The study, published in the journal Nutrients, ​found the human milk oligosaccharide (HMO) promoted beneficial changes in resting fat oxidation, peak aerobic capacity, IL-4, and platelet aggregation and improved participants’ ratings of quality of life.

“These findings indicate that 2′-FL supplementation may offer additional benefits to overweight individuals initiating an exercise and weight-loss program,” wrote the researchers from Texas A&M University, University of Memphis, and University of California Davis.

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The new results expand the beneficial effects​ of 2′-FL, the most prevalent HMO is human milk.

HMOs and weight management

Human milk contains over 200 oligosaccharides, which act as prebiotics to stimulate the growth of beneficial bacteria in infants and support their developing immune systems.

However, scientists have become increasingly interested in the potential benefits of HMOs in adult populations to support health and prevent metabolic diseases.

The current researchers noted an anti-obesity property of 2′-FL by promoting fat oxidation and gut barrier integrity. This suggests the potential to counteract decreased resting energy expenditure (REE) that occurs due to reduced lean body mass in energy-restricted weight loss programs. 

As REE decreases, further weight loss can be difficult, highlighting the importance of preserving lean muscle mass.

The new findings confirm that 2′-FL has the potential to preserve muscle mass during weight loss and has positive effects on the gut, lipid metabolism, inflammation, and microbial composition.


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