Psyched Wellness Ltd. (CSE: PSYC,OTC:PSYCF) (OTCQB: PSYCF) (FSE: 5U9) (the “Company” or “Psyched”), a life sciences company specializing in the production and distribution of health and wellness products derived from the Amanita Muscaria mushroom, is pleased to provide the following corporate update to its investors.

Product Development & Launches

Santa – Dietary Supplement Shot

Following the initial pilot run announced on April 10, 2025, the Company has made significant progress on its new dietary supplement shot, Santa.

On September 15, 2025, the Company completed an initial production run in preparation for a soft launch on October 1, 2025. A second production run is scheduled for mid-October to ensure adequate inventory for the holiday season.

Scientific Studies

On March 14, 2025, the Company initiated a Genotoxicity Study on its proprietary extract, AME-1. The study includes the AMES test, in vitro TK-MLA assay and the micronucleus assay. Progress to date has been promising, and further updates will be shared as results become available.

Additionally, we engaged a third-party laboratory to conduct a six-month accelerated stability study on AME-1. The goal was to evaluate the potential extension of product shelf life beyond the current 12-month period. Results confirm that AME-1 maintains muscimol content up to 18 months and show no microbial growth under accelerated conditions. Accordingly, Calm will now carry an 18-month shelf life.

Patents

Psyched Wellness is pleased to announce that the company submitted a “scaled-up extraction process” application in the USPTO on August 18, 2025, as U.S. Application No. 19/157,676.

The application is now pending in the U.S. and Canada.

Regulatory Update

In July 2025, the Company voluntarily submitted a New Dietary Ingredient Notification (NDIN) to the FDA for AME-1, its proprietary extract of Amanita muscaria. Though AME-1 is only derived from Amanita muscaria, the filing included over 100 years of documented food use of Amanita muscaria in a form that has not been altered along with voluntary toxicology and safety studies of AME-1 conducted by the Company. While the FDA responded in September 2025 that the specific data included in the filing by the Company did not demonstrate that AME-1 “will reasonably be expected to be safe” the Company notes that under the Federal Food, Drug, and Cosmetic Act (“FFDCA“), the purpose of an NDIN requirement is only to notify the FDA, and the submission does not require FDA concurrence or a favorable review in order for the Company to sell its products. Moreover, under the FFDCA the burden rests on FDA to prove a dietary ingredient is unsafe. The Company remains confident in AME-1’s safety based on Amanita muscaria’s historical use and the Company’s safety studies, continues to view itself as fully compliant with FFDCA, and emphasizes its commitment to transparency and regulatory compliance as it brings additional AME-1 products to market.

Psyched Wellness will be growing their route-to-market partnerships, throughout the nation. If you are interested in distributing/listing Calm, please reach out to sales@psyched-wellness.com.

For further information, please contact:

Neither the Canadian Securities Exchange nor its Regulation Services Provider have reviewed or accept responsibility for the adequacy or accuracy of this release.

About Psyched Wellness Ltd.:

Psyched Wellness Ltd. is a Canadian-based health supplements company dedicated to researching and producing consumer packaged goods products derived from our proprietary extract of the Amanita Muscaria mushroom, AME-1.

Cautionary Statement Regarding Forward-Looking Information

This press release contains “forward-looking information” within the meaning of applicable Canadian securities legislation. These statements relate to future events or future performance. The use of any of the words “could”, “proposed”, “intend”, “expect”, “believe”, “will”, “projected”, “estimated” and similar expressions and statements relating to matters that are not historical facts are intended to identify forward-looking information and are based on the Company’s current belief or assumptions as to the outcome and timing of such future events. The forward-looking information and forward- looking statements contained herein include, but are not limited to, statements regarding: the ability of the Company to achieve its scheduled production runs; Company’s expectations regarding regulatory compliance and market introduction of AME-1; the safety of Amanita Muscaria consumption and the safety and purity of any extracts thereof; and the uses and potential benefits of Amanita Muscaria.

Forward-looking information in this news release are based on certain assumptions and expected future events, namely: the Company’s ability to continue as a going concern; the Company’s ability to continue to develop its mushroom-derived products and associated consumer packaged goods; continued approval of the Company’s activities by the relevant governmental and/or regulatory authorities; continued support of safety and risk assessments to support the Company’s evaluation of its products; and the continued growth of the Company.

These statements involve known and unknown risks, uncertainties and other factors, which may cause actual results, performance or achievements to differ materially from those expressed or implied by such statements, including but not limited to: the potential inability of the Company to continue as a going concern; risks associated with potential governmental and/or regulatory action with respect to the Company’s operations; competition within the market; risks with respect to the safety of Amanita Muscaria consumption and the safety and purity of any extracts thereof; and the risk that there is no potential benefit of Amanita Muscaria consumption.

Readers are cautioned that the foregoing list is not exhaustive. Readers are further cautioned not to place undue reliance on forward-looking statements, as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated.

Forward-looking statements contained in this news release are expressly qualified by this cautionary statement and reflect the Company’s expectations as of the date hereof and are subject to change thereafter. The Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, estimates or opinions, future events or results or otherwise or to explain any material difference between subsequent actual events and such forward-looking information, except as required by applicable law.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/269727

We worked with a certified nutrition coach to evaluate and select the top NMN supplements of 2025, providing leaders and innovators a list of clinically backed options to help sustain focus, resilience, and peak performance.

Best NMN Supplements of 2025

Best NMN Supplements Comparison Table

Best NMN Supplement Overall: Omre NMN + Resveratrol

Our Thoughts on Omre NMN + Resveratrol

Omre NMN + Resveratrol is our pick for the best NMN supplement overall because it includes a clinically backed dose of 500 milligrams of ultra-pure NMN and 500 milligrams of micronized trans-resveratrol, paired with BioPerine®, which may help with absorption. 

The resveratrol in this formula is beneficial because it amplifies the benefits of NMN through complementary cellular pathways. We also like Omre’s commitment to third-party testing (COAs are available on the product page) and GMP-certified production, ensuring ingredient purity and safety.

Pete tested this NMN supplement, rating it a 5 out of 5 for his first impression. The supplement comes in a “small, black plastic container with a screw top lid that opens and closes easily,” he said. “The label looks sophisticated, and the company logo is written in gold lettering.” Our team loved the clean, aesthetic look.

He found the instructions to be clear and easily understood, rating them a 5 out of 5. “It says to take two capsules daily in the morning with food, or as recommended by your healthcare professional,” Pete noted. We liked the serving size with this product, making it more convenient for folks who may be taking other supplements. 

Pete rated swallowability of this supplement as a 3 out of 5. He described the pills as “average size clear capsules with an off-white powder inside. The capsules are about one inch in length and one centimeter in diameter.”

Best NMN + Resveratrol Supplement: Wonderfeel Youngr NMN

Wonderfeel Youngr NMN

Includes antioxidants to boost NAD+

Our Thoughts on Wonderfeel Youngr NMN

Wonderfeel Youngr NMN earned our pick for the best NMN + resveratrol supplement because of its science-backed formula that goes beyond basic NAD+ activation. Developed by a Harvard-trained medical expert, it includes NMN, resveratrol, and antioxidants. When paired, NMN and resveratrol have been studied and found to work together to help support healthy aging and improved energy.

This formula combines 20 micrograms of vitamin D (100% of your daily recommended value) with 900 milligrams of NMN and 100 milligrams of trans-resveratrol. Unique to Wonderfeel, this product also includes 50 milligrams of olive extract, which may offer some anti-inflammatory properties. 

Pete tested this NMN supplement, rating it a 5 out of 5 for his first impression. “The container for this supplement is interesting, it looks like a pill and has an easy-to-open screw top lid. The label is blue with both white and yellow labeling, and it’s easy to read,” he said. He thinks the container size should be pretty travel friendly. 

Our tester found the instructions straightforward and easy to understand and follow, rating them a 5 out of 5.  “Take two capsules in the morning with or without food,” he noted. “They’re average size white capsules, about one inch in length and one centimeter in diameter,” Pete said, rating the swallowability a 3 out of 5.

Pete didn’t experience any negative side effects from Wonderfeel Youngr NMN. “The full capsule serving size contains nearly 1,000 milligrams of NMN,” he said. “Most studies on humans are using dosages between 250 and 500 milligrams per day, so this is above that. That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported.”

Best Budget NMN Supplement: Nutricost NMN

Nutricost NMN

A cheap NMN supplement with no added ingredients

Our Thoughts on Nutricost NMN

Nutricost NMN is our pick for the best budget NMN supplement due to its simple, single ingredient and price per serving of $1.13. It’s a budget-friendly way to purchase and start a NMN routine. This product offers a straightforward formula, packing 500 milligrams of NMN per serving. 

Pete tested this NMN supplement, giving it a 5 out of 5 rating for his first impression. “The capsules come in a small, white plastic container with a screw top lid. It’s small enough to be travel-friendly,” he said.

He rated the instructions and ease of following them as a 5 out of 5. The directions say, “As a dietary supplement, take two capsules daily with eight to twelve ounces of water or as directed by your healthcare professional,” Pete noted.

Our tester rated swallowability and taste both as 3 out of 5. He observed that the capsules are of roughly average size, about 1 inch in length and 1 centimeter in diameter. Each pill is a clear capsule with a tan powder inside. Pete felt the pills have a “slightly bitter taste.” 

He thinks the dose is plenty, as 500 milligrams of NMN is the amount that’s commonly used in most human studies. “Efficacy in humans is still being studied, and it seems to be well tolerated by most people,” Pete said. However, this product isn’t ideal for folks who want resveratrol included. In that case, we recommend Wonderfeel Youngr NMN. 

Best Natural NMN Supplement: GenuinePurity Liposomal NMN

GenuinePurity Liposomal NMN

Does not contain any artificial additives, GMOs, gluten, dairy, or soy

Our Thoughts on GenuinePurity Liposomal NMN

GenuinePurity Liposomal NMN is our pick for the best natural NMN supplement because the brand uses all-natural ingredients, combined with a patented liposomal delivery system that improves NMN bioavailability. This helps ensure that each dose survives the digestive process and reaches cells where it supports NAD+ production for energy, repair, and healthy aging. Each batch is third-party tested in cGMP and FDA-registered US facilities, with certificates of analysis provided to verify its filler-free, non-GMO, and allergen-free formulation.

GenuinePurity’s formula is pretty simple, offering 250 milligrams of NMN per serving. That said, the serving size is only one capsule, so if you want a higher dose of NMN, you can simply take two capsules. 

Pete’s first impression of the product was positive; he rated it a 5 out of 5 in this category. The supplement comes in a “small, white plastic container with a screw top lid. It opens and closes easily, and is small enough to be travel-friendly,” Pete said.

The instructions were easy to read and to follow, so Pete rated them a 5 out of 5. “The suggested use is to take one capsule daily, preferably with meals or as by directed by a healthcare professional,” he said. The pills are “small, clear capsules with an off-white powder inside.”

Pete didn’t have any negative side effects or taste. Unlike other options on this list, though, GenuinePurity’s formula does not offer any added, beneficial ingredients. If you’re wanting a product that offers a few more potential perks, we suggest Omre NMN + Resveratrol.

Best Vegan NMN Supplement: PartiQlar Pure NMN

PartiQlar Pure NMN

Contains 500 milligrams of NMN in one capsule

Our Thoughts on PartiQlar Pure NMN

PartiQlar Pure NMN is our pick for the best vegan NMN supplement because it includes pharmaceutical-grade, plant-based NMN with over 99% purity. Pure NMN is third-party tested for purity and potency, free from fillers, allergens, GMOs, and gluten, and manufactured in FDA-registered, GMP-compliant US facilities to ensure quality. 

PartiQlar offers 500 milligrams of NMN per serving in a vegetable cellulose capsule, which is safe for those following a vegan diet. We also especially love that PartiQlar displays their lab testing data directly on the product page—this is exactly the level of transparency you want with a supplement.

Pete rated this product a 5 out of 5 for first impressions. “It’s a small white plastic container with a screw top lid. The label is a dark gray with white lettering that’s easy to read,” he said.

Our tester rated the instructions and ease of understanding them as a 5 out of 5 as well. Of the supplement, Pete said: “It’s an average sized clear capsule with a white powder inside. The recommended serving size is one capsule per day.” Many NMN supplements on our list require at least two capsules per serving size, so we love that this product supplies a clinical dose in one pill.

Pete didn’t experience any side effects or aftertaste when testing these capsules. He says the 500 milligrams of NMN is a dose that’s been clinically studied and should provide the potential benefits that one would look to an NMN supplement for.

Other NMN Supplements We Tested

We tested many NMN supplements hands-on in our lab. Here are a few that we considered but didn’t make our list of top picks, and why.

• We tried Double Wood Supplements NMNH supplement but left it off our list because it’s slightly different from NMN, and is a reduced form. NMNH hasn’t been studied to the same extent and is less proven to have potential anti-aging benefits.
• We also tried Life Force’s Peak NMN. It didn’t make our list because the serving size is three larger-than-usual capsules, and this is a less appealing daily dose.

What is an NMN Supplement?

An NMN supplement is a dietary supplement that has nicotinamide mononucleotide. It’s a molecule found in all living cells that acts as a direct precursor to NAD+ (nicotinamide adenine dinucleotide), which is an important coenzyme for cellular energy, metabolism, and DNA repair. NMN is naturally present in foods like broccoli and avocados, but only in very small amounts, which is why you might be interested in trying a supplement to boost your NMN intake. As we age, our natural NAD+ levels decline, which can lead to decreased energy and slower metabolism. People take NMN supplements to potentially help promote longevity, improve energy production, and protect their cells from oxidative stress.

How We Tested and Selected the Best NMN Supplements

We tested and evaluated NMN supplements and scored them on a scale of 1-5 for factors such as first impressions, easy-to-follow directions, swallowability, side effects, and value. Our testers evaluate the products based on their own individual experiences and preferences. We then review their testing feedback and data to share our findings and recommendations with you.

Formula

When selecting and testing NMN supplements, we worked with a certified nutrition coach to ensure each formula meets the highest standards for efficacy and safety. The evaluation process focuses on clinically supported dosages that reflect current research, seeking NMN products that deliver the optimal amounts shown in peer-reviewed studies. Ingredient quality and transparency are top priorities, and we favored NMN supplements made in GMP-certified facilities, with third-party testing, and free of unnecessary additives.

Taste and Texture

Flavor is a big part of our testing process. We ask our testers to provide feedback on the taste, aftertaste, and swallowability of the NMN supplements. 

Serving Size

Serving sizes for NMN supplements range from a single capsule to multiple pills. Whenever possible, we chose NMN products that required fewer capsules per serving for added convenience.

Third-Party Testing

We selected NMN supplements that have been verified through third-party testing for safety, purity, and label accuracy. This process also screens for harmful substances like heavy metals and pesticides.

For athletes, third-party testing is crucial to confirm there are no banned substances—products should be sport certified. Since the FDA does not regulate supplements, independent verification is essential for safety, accuracy, and consumer trust.

Value

When considering value, we place a higher value on brands that source their ingredients in America and have certifications, such as Informed Choice.

How to Find the Top NMN Supplements for You

NMN supplement needs vary based on your age, lifestyle, and any specific health goals you may have related to energy or cellular support.

Consider these factors when choosing the most suitable NMN supplement for you.

Your Body’s Needs

NMN supplements can support cellular health and energy production, but they aren’t essential for everyone. Think of them as an optional addition to a balanced lifestyle rather than a must-have supplement.

Formula

Everyone has different dietary needs, so it’s worth checking the ingredient list before purchasing. Some NMN formulas include added vitamins, minerals, or supportive compounds like resveratrol, which might align differently with various diet types or fitness goals. If a supplement includes additional nutrients, compare them with your recommended daily values (RDVs) to avoid excess intake. Choosing a formula that complements your existing nutrition can help you make the most of your NMN supplement.

Cost

NMN supplements are typically taken every day, and can be pricey, so you may want to consider your budget before purchasing. Cleaner formulations, meaning those without artificial sweeteners or additives, may cost more because of their higher quality and ingredient sourcing.

Third-Party Testing

Because the FDA does not regulate supplements, third-party testing provides independent verification of a NMN supplement’s safety, purity, and label accuracy. This process protects against risks like mislabeling, contamination, or banned substances, giving you confidence in the products you choose. Independent testing is crucial for ensuring both product quality and safety.

Benefits of NMN Supplements

Much like a protein powder or creatine supplement, NMN supplements can offer an array of health benefits, potentially helping your longevity and metabolic health.

• Supports healthy aging: NMN supplements can potentially slow age-related decline by increasing NAD+ levels, which assist in DNA repair, cellular metabolism, and energy production. Clinical trials show NMN supplementation may improve muscle strength, insulin sensitivity, and protect cellular integrity, leading to healthier aging and longer lifespan.
• Enhances metabolic and physical function: NMN supplementation has been shown to increase physical performance, energy, and metabolic health through its effect on NAD+ levels. Studies reveal improvements in insulin sensitivity and muscle function, with users reporting increased stamina and healthier metabolism, which may help combat fatigue and support active lifestyles.

How to Take NMN Supplements

NMN supplements are typically taken in the morning, ideally on an empty stomach, to align with your body’s natural NAD+ production cycle and to optimize absorption and daytime energy benefits. Consistent daily use is important to ensure that you get the benefits of the supplement. NMN supplements aren’t a magic pill, unfortunately. While they may help support healthy aging when taken consistently over time, we still recommend prioritizing healthy habits, like a well-rounded diet and regular exercise plan.

What to Avoid in NMN Supplements

There are important factors to avoid when selecting a NMN supplement:

• Avoid impurities and poor manufacturing practices: Choose a NMN supplement that is certified by third-party organizations, such as cGMP-certified. It’s also important to look for the product’s certificate of analysis showing test results on the product page.
• Avoid unnecessary filler ingredients: Some NMN supplements include fillers or preservatives that can cause allergic reactions or digestive discomfort, especially in those sensitive to soy, gluten, or common preservatives. Avoid proprietary blends that do not transparently disclose the NMN content, as these make it harder to track the exact dosage you are getting.

Frequently asked questions

An expert is revealing the reality of a popular supplement that has been touted as an ‘essential nutrient.’

Trivalent chromium, a metal, is included in multivitamin pills and sold as a dietary supplement that companies claim can improve athletic performance and help regulate blood sugar.

But Neil Marsh, a professor of chemistry and biological chemistry at the University of Michigan, said although health agencies in the US recommend chromium as a dietary requirement, eight decades of research have resulted in slim evidence that people derive any significant health benefits from this mineral.

Still, chromium has come to be considered essential for human health. 

To stay healthy, people need essential trace elements, very small amounts, in their diet. These include metals such as iron, zinc, manganese, cobalt and copper. 

For most of these trace elements, decades of research have shown they are genuinely essential for health. 

Iron is essential for carrying oxygen in your blood, and many proteins – complex molecules that carry out all of the functions necessary for life – require iron to function properly. 

A deficiency of iron leads to anemia, a condition that results in fatigue, weakness, headaches and brittle nails, among other symptoms. Iron supplements can help reverse these symptoms.

Importantly, biochemists have pinpointed exactly how iron helps proteins perform essential chemical reactions, not just for humans but all living organisms. Researchers know not only that iron is essential but also why it is essential.

However, the same cannot be said for chromium.

Chromium deficiency – having little to no chromium in your body – is extremely rare, and researchers have not identified any clearly defined disease caused by low chromium levels.

Like all food, essential metals must be absorbed by your digestive system. However, the gut absorbs only about 1 percent of ingested chromium. Other essential metals are absorbed more efficiently – for example, the average person absorbs around 25 percent of certain forms of ingested iron.

Despite many studies, scientists have yet to find any protein that requires chromium to carry out its biological function. Only one protein is known to bind to chromium, and this protein most likely helps your kidneys remove the metal from your blood. 

While some studies in people suggest chromium might be involved to some degree in regulating blood glucose levels, research on whether adding extra chromium to your body through supplements can substantially improve your body’s ability to break down and use sugar has been inconclusive.

Thus, based on biochemistry, there is currently no evidence that humans, or other animals, actually require chromium for any particular function.

The idea that chromium might be essential for health stems from studies in the 1950s, a time when nutritionists knew very little about what trace metals are required to maintain good health.

One influential study involved feeding lab rats a diet that induced symptoms of Type 2 diabetes. 

Supplementing their diet with chromium seemed to cure the rats of Type 2 diabetes, and medical researchers were enticed by the suggestion that chromium might provide a treatment for this disease. 

Today’s widespread claims that chromium is important for regulating blood sugar can be traced to these experiments.

Unfortunately, these early experiments were very flawed by today’s standards. They lacked the statistical analyses needed to show that their results were not due to random chance. 

Furthermore, they lacked important controls, including measuring how much chromium was in the rats’ diet to start with.

Later studies that were more rigorously designed provided ambiguous results. 

While some found that rats fed chromium supplements controlled their blood sugar slightly better than rats raised on a chromium-free diet, others found no significant differences. But what was clear was that rats raised on diets that excluded chromium were perfectly healthy.

Experiments on people are much harder to control for than experiments on rats, and there are few well-designed clinical trials investigating the effects of chromium on patients with diabetes. Just as with the rat studies, the results are ambiguous. If there is an effect, it is very small.

Still, there has been a recommended dietary intake for chromium despite its lack of documented health benefits. 

The idea that chromium is needed for health persists due in large part to a 2001 report from the National Institute of Medicine’s Panel on Micronutrients. 

This panel of nutritional researchers and clinicians was formed to evaluate available research on human nutrition and set ‘adequate intake’ levels of vitamins and minerals. 

Their recommendations form the basis of the recommended daily intake labels found on food and vitamin packaging and the NIH guidelines for clinicians.

Despite acknowledging the lack of research demonstrating clear-cut health benefits for chromium, the panel still recommended adults get about 30 micrograms per day of chromium in their diet. 

This recommendation was not based on science but rather on previous estimates of how much chromium adult Americans already ingest each day. Notably, much of this chromium is leached from stainless steel cookware and food processing equipment, rather than coming from our food.

So, while there may not be confirmed health risks from taking chromium supplements, there’s probably no benefit either.

This article is adapted from The Conversation, a nonprofit news organization dedicated to sharing the knowledge of experts. It was written by Neil Marsh, a professor of chemistry and biological chemistry at the University of Michigan.